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Meredith Grey is the daughter of one of the profession's most respected surgeons. Now, she wants to follow in her mother's footsteps at Grace Hospital in Seattle. Grey is presented as the cornerstone of the series from which different conflicts will arise in relation to her lover, neurosurgeon Derek Shepherd; her best friend, Dr. Cristina Yang, and the rest of the doctors at the hospital, especially the interns in training, such as Alex Karev, Izzie Stevens or George O'Malley.

The series revolves around this group of surgeons, physicians and interns, the medical cases they deal with in each episode and the interpersonal relationships that take place between them. The intensity of medicine is brought out through these conflicts and also through the interns' race to become doctors.

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